“Intra-articular corticosteroid, hyaluronic, or PRP injections can provide short-term to medium-term (4 to 12 weeks) improvement in pain and function as measured by either WOMAC and/or VAS scores (standard pain and functional assessment scores) with minimal incidence of serious adverse events. There is a scarcity of head-to-head comparisons between each injectable therapy, although there is some emerging evidence that suggest possibly superior pain reduction with hyaluronic over the long-term (6 months to 1 year) compared to hyaluronic. ![]() An opinion on Intra-articular corticosteroid, hyaluronic, or PRP injections for knee pain.Ĭompare this to a 2021 study ( 2) which could not make a clear recommendation but suggested “superior and sustained pain improvements with Platelet Rich Plasma (PRP) over the longer term (6 months to 1 year)” Moreover, the greatest improvement of pain and function at 12 months compared with baseline were observed in mesenchymal stem cells (MSCs) intervention groups. The research team concluded: Among all the interventions studied, the results of mesenchymal stem cells (MSCs) and PRP were the most consistent and associated with improvement in pain and articular function on the long-term. Mesenchymal stem cells (MSCs) had the highest probability to be the best treatment with primary outcome and also associated with improvement in pain and function especially at mid and long term. Otherwise, the combination of hyaluronic acid and dexamethasone (steroid) was not associated with improvement in WOMAC at 3 and 6 months compared with the injection of hyaluronic acid alone. The results of NSAID alone or with physical exercise (physiotherapy) were not associated with improvement in pain and function compared with the injection of hyaluronic acid. ![]() Ozone injection showed no improvement in pain and function at 12 months. Ozone injection is the only intervention for which knee pain and/or function got worse at the end of the study compared with the baseline.Corticosteroid improved outcomes but did not perform better than the control or placebo.Mesenchymal stem cells and PRP were significantly better than the chosen control (placebo) and associated with improvement in knee status.Using a primary outcome scoring system – the WOMAC or Western Ontario and McMaster Universities Osteoarthritis Index, universally used by health professionals to evaluate the condition of knee osteoarthritis patients), these are the findings: The authors wrote: “The interventions had different effects on the participants suffering from knee osteoarthritis.” How? Administration of nonsteroidal anti-inflammatory drugs with physical therapy.Administration of nonsteroidal anti-inflammatory drugs,.Mesenchymal stem cells (MSCs), Mesenchymal stem cells are injected into a damaged joint and surrounding area, of stem cells drawn from the patient’s own bone marrow.I discuss Platelet Rich Plasma (PRP) further below. The collected platelets and their healing elements are then injected back into the injured area to stimulate healing and regeneration. PRP treatments involve collecting a small amount of your blood and spinning it in a centrifuge to separate the platelets from the red cells.The authors wrote that their goal was to “find out, based on the available recent randomized controlled trials (RCTs), if the nonsurgical interventions commonly used for knee osteoarthritis patients are valid and quantify their efficiency (prove their effectivness).” The treatments assessed were: Seven different knee osteoarthritis treatmentsĪ December 2021 study ( 1) assessed seven different knee osteoarthritis treatments. In the research below various comparisons are made between the different types of knee injections. Most want to know “which works the best?” Let’s have researchers answer that question. These people come to see us because they are exploring non-surgical alternatives and have investigated various types of knee injections. Many patients we see have been researching their options in managing their chronic knee pain.
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